Wound infection used to be a major cause of disability and mortality. The introduction of antisepsis techniques and antibiotics have dramatically changed the course of wound healing. Despite these advancements, with the excessive use of antibiotics and the appearance of resistant strains of bacteria, wound healing has become more medically and financially significant globally. Congestion of high-speed modes of transportation, enhanced weaponry’s destructive capacity and  occupational accidents lead to increase in hard-to-cure trauma-related wounds. The extension of life-expectancy with the increase in chronic diseases: PVD, diabetes and diabetes-associated foot, all add to the upsurge of hard to heal wounds and constituting wound healing as a major global issue.


  Dr. Topaz is conducting ongoing basic science and clinical research pertaining to the application of new and advanced medical technologies in the field of wound healing. He is presently performing research at the Hillel Yaffe Medical Center in Hadera and the Bar Ilan University in collaboration with university hospitals in China (The People's Hospital of Deyang in Sichuan, The Second People's Hospital in Taiyuan, the Feyang Hospital in Shanxi and the Fourth Military Hospital in Xi'an) .
 
For over five years Dr. Topaz has been lecturing and performing surgery in China on a regular basis. His lectures focus primarily on wound healing by the RNPT (Regulated Negative Pressure Therapy)  and the RO-NPT (Regulated Oxygen-enriched Negative Pressure-assisted wound Therapy) in an effort to implement RNPT and RO-NPT as advanced and innovative platform technologies integrated with inventive original devices in an approach to better treatment and wound healing.